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In the combined analysis of the DELIVER (Dapagliflozin Evaluation to Improve the Lives of Patients with Preserved Ejection Fraction Heart Failure) and DAPA-HF (Dapagliflozin and Prevention of Adverse-outcomes in Heart Failure) trials and the DEFINE-HF (Dapagliflozin Effects on Biomarkers, Symptoms, and Functional Status in Patients with Heart Failure with Reduced Ejection Fraction) and PRESERVED-HF (Effects of Dapagliflozin on Biomarkers, Symptoms and Functional Status in Patients with Preserved Ejection Fraction Heart Failure) trials, there were consistent benefits of dapagliflozin on both clinical events, as well as health status across the spectrum of LVEF, with no suggestion of attenuated benefit at higher LVEF

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