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Vegetarians and vegans : Since B12 is primarily found in animal products, individuals who follow plant-based diets may need B12 supplementation
Foundational GHK-Cu (sister peptide) paper: stimulates collagen synthesis in human fibroblasts, effect beginning at 10^-12 to 10^-11 M and maximal at 10^-9 M the same potency window later reported for AHK-Cu, establishing the copper-tripeptide mechanism
This baseline concentration establishes tolerance while still delivering meaningful peptide activity
It can also cause more pain at the injection site because muscle tissue has more nerve endings than fat
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