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Unfortunately, PF-4840154 is a hERG K + channel inhibitor and it has the predicted adverse side effect to induce cardiac arrhythmia 22
Tirzepatide is a dual GLP-1 and GIP receptor agonist designed for once-weekly injection, and many patients need to shift their injection day for convenience, travel, or lifestyle changes
For instance, when initiating GLP-1 therapy, a gradual reduction in insulin doses can help prevent diabetic ketoacidosis
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