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Standard recommendations span a few weeks to months depending on the dose and medical history

Because losing at least 5% of fasting body weight through lifestyle intervention during the 4- to 12-week run-in was a condition for their continued participation in the randomized treatment period, the results may not reflect those expected in the general population

Safarinejad MR, Shafiei N, Safarinejad S (2010) The association of glutathione-S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) with idiopathic male infertility