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196 Patients with migraine and insulin resistance who received ALA (400 mg twice daily) for 6 months experienced a reduction in the number of migraine attacks and days of treatment, although there was no improvement in insulin sensitivity in this study
It works by: Slowing gastric emptying , which prolongs feelings of fullness after eating Reducing appetite through effects on brain regions that regulate hunger Improving glycaemic control by enhancing insulin secretion when blood glucose is elevated Reducing glucagon secretion , which helps prevent excessive glucose production by the liver The medication is administered as a once-weekly subcutaneous injection, with doses gradually increased over 16-20 weeks to the maintenance dose of 2.4 mg weekly (though some patients may remain on 1.7 mg if the higher dose is not tolerated)
However, the response is distinct in chronic inflammatory diseases such as atherosclerosis in diabetic mice and diabetic nephropathy [30, 31]
median follow-up 2.1 years), which proved instrumental in the approval process
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