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SPMs can decrease levels of pro-inflammatory cytokines, such as IL-1, IL-6, and tumor necrosis factor (TNF)-, through activating their G protein-coupled receptors, thus causing activation of anti-inflammatory transcription factors, such as peroxisome proliferator-activated receptor gamma, and down-regulating intracellular NF-kB signaling pathway (63)
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Long-term human safety and efficacy remain under investigation [4]
I was not an alcoholic but a binger
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