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However, because they both act on the same metabolic pathways, the intensity of their effects can be magnified
IGF-1 LR3 has a longer half-life compared to the base form of IGF-1, allowing for a longer duration of activity in the body
Thats why drugs like GLP-1 agonists have gained popularity for their appetite-suppressing effects, with their use increasing by 111% in the United States between 2020 and 2022
This rebound effect is why doctors recommend a gradual dose reduction rather than abrupt cessation
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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