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After solubilization, the samples were analyzed for H and C content using dual window scintillation counting

In another RDP study on 20 patients with CVI, Pycnogenol supplementation (300 mg/day for two months) reduced venous pressure significantly by 9.8 and 8.3% (right and left legs, respectively) compared to baseline (33)

This stabilizes the transcription factor BACH1, which subsequently upregulates angiogenesis-related factors, including PDGFB, EGFR, FGF2, and FGFR1, ultimately driving vascular regeneration