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In vitro BBB models have revealed the role of BBB adhesion molecules, including ICAM-1, E-selectin, and PECAM-1, in transmigration of monocytes (Sguin et al., 2003), dendritic cells (Sagar et al., 2012), neutrophils (Wong et al., 2007), and lymphocytes (Wong et al., 1999)

Injecting at the same time each week keeps those levels as stable as possible, which reduces the likelihood of breakthrough side effects from concentration peaks and valleys

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