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Mitochondrial glutamine transport is especially important in tissues like the brain, heart, and muscles, where high mitochondrial activity is required for processes like ATP generation, protein synthesis, and neurotransmitter production
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Consistent with our previous data which indicated a protective role of GSH under cystine-deprived conditions, cell death was most severe when both cystine and GSH were depleted in HepG2 cells (Fig
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