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In the Phase 2 retatrutide trial ( Jastreboff et al., NEJM 2023 ), body-composition imaging showed fat mass falling substantially more than lean mass, meaning the majority of the weight lost was fat

Structure, inactivation, and roles of p53 in diseases p53 structural domains and their functional implications p53 structural domains The p53 protein, encoded by the TP53 gene located on chromosome 17p13.1, is composed of 393 amino acids (AAs) and contains a wide range of functional domains