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SASP is characterized by the release of inflammatory and tissue-degrading molecules that can impair tissue function and structure, potentially leading to age-related deterioration

This pulsatile pattern is considered more physiologically appropriate than continuous GH elevation, and is preserved across multiple administration cycles

Patients with lower baseline glutathione or elevated oxidative stress markers may benefit from more frequent glutathione dosing, while tirzepatide tolerability often depends on GI capacity and pancreatic lipase stability

Timing: 10 minutes before breakfast and again 10 minutes before lunch