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In clinical trials of semaglutide injection for weight management, cholelithiasis was reported in 1.6% of semaglutide-treated patients compared with 0.7% of placebo-treated patients

Mechanistic investigations associate these outcomes with signaling pathways involving vascular endothelial growth factor receptor-2 (VEGFR-2) and downstream Akt-eNOS activation, processes that collectively facilitate efficient muscle tissue remodeling (5)

Although causality is debated and absolute risk is low, clinicians should be alert to severe abdominal pain and elevated pancreatic enzymes and stop therapy if pancreatitis is suspected

The other components are not specifically named on the current Prohibited List