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It is important to recognize that Wegovy is not designed for rapid weight loss but for sustained, long-term metabolic improvement

[1] [2] In such cases, testing before meals and at bedtime may be appropriate, particularly during dose titration

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Similarly, the highly anticipated EVOKE and EVOKE+ phase 3 trials of oral semaglutide in early Alzheimers disease reported in November 2025 that semaglutide failed to meet its primary endpoints : while it reduced several AD-related biomarkers by up to 10%, these changes did not translate into cognitive or functional benefit ( [72] )