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In endogenously expressing cell models, retatrutide showed activity comparable to native glucagon in human iPS-derived hepatocytes (a GCGR-predominant system) and stronger activity than native GIP in human differentiated adipocytes (a GIPR-predominant system)
Serious side effects and their symptoms can include the following: Anaphylaxis (severe allergic reaction): Seek emergency medical help if you develop urticaria (hives), difficulty breathing, or edema (swelling) Dysuria (painful or burning urine) Cloudy, red, pink, brown, or strong-smelling urine Fever-related symptoms Back pain Nausea Vomiting Pelvic pain Rectal pain Vaginal odor, discharge (which may be lumpy or have a cottage cheese-like appearance), or itching Redness, itching, swelling, or rash of the penis or the skin around the penis
A., Tonneijck, L., Smits, M
Nicholls FA et al
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