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Gln, a nonessential amino acid abundant in the bloodstream, along with its metabolites lutamate and ketoglutarate (-KG), serves as a vital source of carbon and nitrogen, providing essential raw materials for the synthesis of nucleotides and amino acids ( Although some Gln metabolic inhibitors have entered clinical trials, the heterogeneity among tumors complicates their effectiveness

The GLP1RAs (glucagon like peptide 1 receptor agonists) are in widespread use as they can promote weight loss and have been shown to improve cardiovascular outcomes in randomized trials

eGFR, estimated glomelural filtration rate

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