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Cisplatin and 5-fluorouracil with or without epidermal growth factor receptor inhibition panitumumab for patients with non-resectable, advanced or metastatic oesophageal squamous cell cancer: a prospective, open-label, randomised phase III AIO/EORTC trial
If SAH accumulates, homocysteine is poorly managed or sulfur-amino-acid substrate is inadequate, the liver may have less flexibility to maintain methylation while also supplying cysteine for glutathione and taurine
No dramatic visible change yet, and thats normal
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