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That single observation can reveal a late-cycle effect

Decreased food intake in semaglutide-treated mice was associated with decreased meal size ( Figure 2C-D )

This suggests that DPP-4 inhibitors, which are commonly used for treating type 2 diabetes mellitus (T2DM), may offer therapeutic benefits beyond glycemic control, potentially mitigating bone resorption and reducing fracture risk [23]

Key distinctions include: GLP-1 therapies primarily reduce appetite support blood sugar regulation encourage gradual weight loss Retatrutide reduces appetite improves insulin sensitivity increases metabolic rate promotes fat oxidation may support lean muscle preservation This broader metabolic influence is why researchers believe triple-agonist peptides may represent the next evolution of medical weight management therapies