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Nuclei were labelled with Hoechst33342 (H1399, Thermo Fischer)

However, after exendin-4 stimulation, the receptor association with clathrin-positive regions increased, an effect that correlates with the known rapid GLP-1R internalisation triggered by exendin-4 (31), with this increase however significantly less pronounced for the GLP-1R V229A compared to WT (F/S = 0.16 0.006 and 0.10 0.004 for WT versus V229A, respectively), in agreement with the reduced internalisation propensity displayed by this mutant receptor (Figure 2H)

Trends in the epidemiology of the first attack of acute pancreatitis: a systematic review

2024;22(6):1226-37 e14