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Dose adjustment considerations: If gastrointestinal symptoms are severe or persistent despite these measures, contact your prescribing clinician to discuss: Slowing the dose escalation schedule Temporarily reducing the dose Taking a brief treatment pause (though this may affect weight loss progress) Switching to an alternative weight management medication if symptoms are intolerable The STEP trials demonstrated that slower dose titration can reduce the incidence and severity of gastrointestinal adverse effects

Zheng Z K, Zong Y, Ma Y Y, et al

Glutathione is a powerful antioxidant naturally produced in the liver

Symptoms include severe, persistent abdominal pain radiating to the back, often accompanied by nausea and vomiting that differs qualitatively from the typical GI side effects