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( A and B ) Weight gain of PAR2-G37I, PAR2-R38E, and WT male ( n = 19/16/13) ( A ) and female ( n = 7/7/7) ( B ) mice on HFD

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2f), indicative of pseudo first order reaction kinetics

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This is noteworthy as these analogues are at least 10-fold less potent then GLP-1-G 2 ( 1 ), meaning that even if at least 10 times more compound is required to get the same activity in vitro, they have a significant longer acting period

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