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In this context, even moderate increases in oxidative demand can favor conditions that increase mitochondrial electron leakage and ROS formation, particularly when respiratory reserve and redox-buffering capacity are reduced
Nevertheless, a systematic assessment of their therapeutic applications, mechanisms, and clinical translation challenges in IMIDs remains lacking
10.1016/j.jamda.2020.02.022 160
Some doctors may be open to exploring it if they feel the potential benefits outweigh the risks, while others may be hesitant due to the lack of clinical evidence specific to RA
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