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doi: 10.1007/s00018-015-2080-2 7 KartikaRWibowoH

Retinoids in the Treatment of Skin Aging: An Overview of Clinical Efficacy and Safety

[28] Normally, this would be a concern, since insulin can be considered the "energy storage hormone", but its appetite suppressive properties (due to delayed gastric emptying) tilt the scales towards more weight loss -- the point where it's become more than just antidiabetic drug