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When to pause or stop Most side effects resolve with time and do not require protocol changes
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Quality and regulation : Most oral B12 supplements are regulated as food supplements under food law, while injectable B12 and some oral preparations are licensed medicines regulated by the MHRA
With reduced preload the heart does not have to exert as much contractile force which reduces the oxygen requirements of the heart and also reduces ventricular transmural pressure resulting in reduced compression of the coronary arteries allowing for more efficient blood flow through the heart
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