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The antioxidant effects of GPx1 are achieved by the direct reduction of hydrogen peroxide and lipid hydroperoxides [13]

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Figure 1 demonstrates the acyl-carnitine elevations in brain homogenates found in rats exposed to intracerebroventricular infusions of PPA as compared with those exposed to phosphate buffered saline vehicle control

While hyperkalaemia occurred more frequently with finerenone than with placebo, this was often mild or moderate and resulted in few drug discontinuations (2.3% vs 0.9%, respectively), despite study participants also being on maximum-tolerated RAS inhibitor therapy