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2017;312:C749C764

We believe this timeframe should be sufficient to show the effects of GLP-1 receptor agonists and SGLT-2 inhibitors because mechanistic studies have found rapid effects of GLP-1 receptor agonists on potassium handling,2425 and post hoc analyses of randomized trials of SGLT-2 inhibitors have shown separation of survival curves within one year for hyperkalemia.2223 Finally, our findings are representative of the insured population in the United States, but might not be generalizable to uninsured patients

Because the GLP-1 and GIP receptors are present throughout the body, GLP-1 therapy can have anti-inflammatory effects on multiple tissues

Performance margin is expected between 46% and 47.5%, suggesting operating leverage continues to improve even as manufacturing scales rapidly