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doi: 10.1042/BSR20181995 35 FangBLiuFYuXLuoJZhangXZhangTet al
Patients begin at a starting dose, then increase their dose on a defined schedule until they reach a maintenance dose
The report was uncontrolled, unblinded, not randomized, had no comparator arm, used patient-reported outcomes rather than validated pain instruments, and did not publish dose, effect size, confidence intervals, p-values, or systematically collected adverse events limitations that severely constrain any clinical inference
For men it is recommended to ensure viability of sperm
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