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Using health records from over five million pregnancies and more than three million live births between 1992 and 2023, researchers observed a dose-response relationship: one pre-pregnancy CT scan was linked to an 8% increase in miscarriage and a 6% rise in congenital abnormalities, two scans raised risks by 14% and 11%, and three or more scans by 19% and 15%, respectively
423 The research further demonstrated that this anti-inflammatory effect was not mediated by GLP-1R in the blood or endothelial cells but required the GLP-1R in the CNS
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