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Results were expressed relative to individual well baseline and AUC was calculated

According to the SURMOUNT clinical trials, gastrointestinal adverse events occur in a substantial proportion of patients, particularly during dose escalation phases

J Biol Chem 284(14):90599065 Wada K, Hiratake J, Irie M, Okada T, Yamada C, Kumagai H, Suzuki H, Fukuyama K (2008) Crystal structures of Escherichia coli gamma-glutamyltranspeptidase in complex with azaserine and acivicin: novel mechanistic implication for inhibition by glutamine antagonists