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Journal of Orthopaedic Surgery and Research

HMGB1, a ligand of TLR4, can shuttle between the nucleus and cytoplasm

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In response to growth signals, mTORC1 activates ATF4, which stimulates the expression of core enzymes in serine synthesis and the folate cycle for de novo purine synthesis required for DNA replication and ribosome biogenesis in rapidly growing and proliferating tumor cells (Denicola et al., 2015

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