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Moreover, maintenance of clearance was observed in 54.5% of patients at 15 months

Study authors included studies where participants took oral L-carnitine supplements for at least seven days

The lack of central carbon and nitrogen catabolism not only leads to energy deficiency but also reduces the supply of the main metabolite anabolic precursors such as pyruvate, acetyl-CoA, glucose-6-phosphate, and erythrose 4-phosphate used for biomass biosynthesis 21