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Patients using injectable semaglutide should take levothyroxine at the same time each day, preferably on an empty stomach
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Future directions First, define exposureresponse with quantitative pharmacokinetics and, where possible, receptor-occupancy or target-engagement biomarkers to guide dose selection across tissues
Notably, the so-far available evidence on GIP/GLP-1 RAs efficacy in T2DM is striking, with tirzepatide (15 mg once weekly) appearing superior both compared to placebo and GLP-1RAs for glycemic control and body weight reduction, and also superior to basal insulin for glycemic control, without increasing the risk for hypoglycemia
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