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PINK1/Parkin-dependent mitophagy can effectively eliminate damaged mitochondria, mitigating elevated ROS and preserving metabolic fitness
Subsequent studies further revealed that both TNF- and LPS activate the c-Jun N-terminal kinase (JNK) pathway to phosphorylate IRS-1 at Ser307, which blocks PI3K/Akt signaling and consequently impairs glucose uptake (45)
[11] Overall, pyridoxine HCl Injection can be used in pregnant patients if needed for deficiency or other indications, with prudent dosing and medical oversight
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