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Key findings from genetically modeled GLP1R/GIPR agonism: Lower binge-drinking frequency Reduced risk of heavy drinking with psychiatric comorbidities Improved liver health (lower NAFLD & ALT) Cardioprotective effects partially mediated by reduced alcohol use Consistent results across ancestries With AUD treatment access still critically low, these insights highlight a promising new frontier: repurposing metabolic therapies for addiction medicine

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Liu Y, Ruan B, Jiang H, Le S, Liu Y, Ao X, et al