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In contrast, DIO mice in both groups switched from WD to LD each had significantly increased Proteobacteria relative abundance (represented solely by the genus Parasutterella ) compared to both the WD and the LD controls, suggesting that Proteobacteria relative abundance may be largely influenced by stress or the differences in net energy expenditure (or associated body weight changes) caused by the diet switch

Asian J Androl 16:3138

Rather than assuming uniform proteostasis failure mechanisms across individuals, single-cell omics and AI-guided analytics now allow the development of individualized proteostasis signatures, capturing differences in pathway dominance, compensatory potential and disease vulnerability

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